Is your GLP-1 journey interrupted by heartburn?

Talk to your doctor to see if PEPCID^® is the right choice for you.

One Dose for Fast, Long Lasting Heartburn Relief.

Is your GLP-1 journey interrupted by heartburn?

Why heartburn may occur during your GLP-1 journey

GLP‑1 medications slow digestion, so food stays in your stomach longer which may make your stomach feel full for a longer period of time. For some people, this can also increase stomach pressure, which may cause mild digestive discomfort such as heartburn or indigestion.
If you already experienced heartburn before starting a GLP‑1 medication, you may also experience heartburn while taking it.
It’s important to note that heartburn can happen for many reasons and may occur even when it’s not related to GLP‑1 medication.

How PEPCID COMPLETE^® Can Help

From the #1 doctor recommended OTC acid reducer brand, PEPCID COMPLETE® provides dual action heartburn relief that works fast and lasts. It combines an antacid that starts neutralizing acid instantly and an H2 blocker, famotidine, that helps control acid all day or all night.**

_{*Consult a doctor or pharmacist before starting any over the counter medications while on a prescription. Antacids and acid reducers may interact with certain prescription drugs. Kenvue does not sell, endorse, or promote the use of any particular GLP-1 medicine. Use product only as directed.}

_{**Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.}

Our Heartburn Relief Products

PEPCID COMPLETE® Chewable Tablet with Famotidine & Antacids

Maximum Strength PEPCID AC® Tablets with Famotidine

Maximum Strength Pepcid AC in Icy Cool Mint Flavor 40 tablets

PEPCID AC® Maximum Strength Heartburn Relief & Acid Reducer, Icy Cool Mint, 20 mg Famotidine Tablets

PEPCID COMPLETE® ON-THE-GO Chewable Tablet with Famotidine & Antacids

Original Strength PEPCID AC® Tablets with Famotidine

Antacids vs PEPCID COMPLETE^® vs PPIs

	Antacid (ex: Tums)	PEPCID COMPLETE®	PPI (ex: Prilosec or Nexium)
How it works?	Neutralizes stomach acid	Neutralizes stomach acid Blocks the signal that tells the stomach to produce acid	Turns off the stomach’s acid‑producing pumps to greatly reduce acid
Characteristics	Fast onset	The only OTC brand that starts to work instantly and lasts all day*	2–5 days to peak effect
Effectiveness	Provides fast relief, short duration of relief for heartburn symptoms May require multiple doses	Provides fast, long-lasting relief in 1 dose	Provides long term relief

Lifestyle Tips for Managing Heartburn on GLP-1s

Some people taking GLP‑1 medicines may notice gastrointestinal reactions such as heartburn, fullness, or indigestion. These symptoms are usually temporary and can often be improved with simple lifestyle and eating adjustments.

1. Eat Smaller Meals, More Often

Large meals can make your stomach feel too full and increase heartburn symptoms when digestion slows. Eating smaller portions more frequently may help reduce discomfort.

2. Build a “GLP‑1‑Friendly Plate”

Aim for balanced meals that are easier to digest.

3. Keep Dinner Light and Earlier

Eating heavy or late meals may worsen nighttime heartburn. A lighter dinner earlier in the evening can help reduce heartburn while you sleep.

4. Eat Slowly and Stay Upright

Taking your time while eating and staying upright for at least 2–3 hours after meals may reduce heartburn symptoms.

5. Watch Foods That Trigger Reflux

Some foods may worsen symptoms.

Commonly asked question:

How do I know when to stop taking a PPI?

The frequency of heartburn may decrease during your GLP-1 journey at any time. Talk to your doctor about any changes that are recommended for your heartburn medications.

All Articles