Why heartburn may occur during your GLP-1 journey
GLP‑1 medications slow digestion, so food stays in your stomach longer which may make your stomach feel full for a longer period of time. For some people, this can also increase stomach pressure, which may cause mild digestive discomfort such as heartburn or indigestion.
If you already experienced heartburn before starting a GLP‑1 medication, you may also experience heartburn while taking it.
It’s important to note that heartburn can happen for many reasons and may occur even when it’s not related to GLP‑1 medication.
*Consult a doctor or pharmacist before starting any over the counter medications while on a prescription. Antacids and acid reducers may interact with certain prescription drugs. Kenvue does not sell, endorse, or promote the use of any particular GLP-1 medicine. Use product only as directed.
**Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. Acid control does not imply symptom relief.
Our Heartburn Relief Products
Antacids vs PEPCID COMPLETE® vs PPIs
Antacid (ex: Tums) | PEPCID COMPLETE® | PPI (ex: Prilosec or Nexium) | |
|---|---|---|---|
How it works? |  Neutralizes stomach acid |  Neutralizes stomach acid |  Turns off the stomach’s acid‑producing pumps to greatly reduce acid |
Characteristics | Fast onset | The only OTC brand that starts to work instantly and lasts all day* | 2–5 days to peak effect |
Effectiveness | Provides fast relief, short duration of relief for heartburn symptoms May require multiple doses | Provides fast, long-lasting relief in 1 dose | Provides long term relief |
Lifestyle Tips for Managing Heartburn on GLP-1s
Some people taking GLP‑1 medicines may notice gastrointestinal reactions such as heartburn, fullness, or indigestion. These symptoms are usually temporary and can often be improved with simple lifestyle and eating adjustments.
1. Eat Smaller Meals, More Often
Large meals can make your stomach feel too full and increase heartburn symptoms when digestion slows. Eating smaller portions more frequently may help reduce discomfort.
2. Build a “GLP‑1‑Friendly Plate”
Aim for balanced meals that are easier to digest.
3. Keep Dinner Light and Earlier
Eating heavy or late meals may worsen nighttime heartburn. A lighter dinner earlier in the evening can help reduce heartburn while you sleep.
4. Eat Slowly and Stay Upright
Taking your time while eating and staying upright for at least 2–3 hours after meals may reduce heartburn symptoms.
5. Watch Foods That Trigger Reflux
Some foods may worsen symptoms.
FAQ
✝Consult a doctor or pharmacist before starting any over the counter medication while on a prescription. Antacids and acid reducers may interact with certain prescription drugs. Kenvue does not sell, endorse or promote the use of any particular GLP-1 medicine. Use product only as directed.