Both PEPCID® and ZANTAC 360°® are a Histamine-2 blocker (H2 blocker) with the active ingredient famotidine. Famotidine helps relieve heartburn by reducing the amount of acid in the stomach.
PEPCID® is the original famotidine brand and has been clinically proven to be safe and effective at providing fast heartburn relief for 35 years when used as directed. Backed by 50+ clinical studies, PEPCID® is the #1 doctor recommended acid reducer brand in the market.
Explore the chart below to compare Original Strength PEPCID AC®, Maximum Strength PEPCID AC® and PEPCID COMPLETE® to ZANTAC 360°® Maximum Strength and ZANTAC 360°® Original Strength. Please speak with your healthcare provider about which heartburn treatment option might be right for you.
 |  | |
|---|---|---|
Classification | ||
H2 Blocker | H2 Blocker | |
Active Ingredient | ||
Famotidine | Famotidine | |
Adult Dosing | ||
1 tablet | 1 tablet | |
Intended Use | ||
Treats unexpected heartburn Prevents heartburn5 Controls acid all night2 | Treats unexpected heartburn Prevents heartburn5 Controls acid all night2 | |
Onset of Heartburn Relief | ||
Starts to work in minutes1 | Starts to work in minutes1 | |
Duration of Acid Control or Neutralization | ||
Up to 12 hours2 | Up to 12 hours2 | |
Form | ||
Tablet | Tablet | |
Original Famotidine Brand, Clinically Proven Heartburn Relief for 35 Years | ||
#1 Doctor Recommended Acid Reducer Brand
| ||
#1 Gastroenterologist Recommended Acid Reducer H2 Blocker Brand | ||
Backed by 50+ Clinical Studies | ||
PEPCID® provides fast heartburn relief in minutes and lasts all day.*
*Starts to relieve heartburn in 15-30 minutes. Based on 8 hours of symptom relief studies during the day.
1. Starts to relieve heartburn in 15-30 minutes.
2. Based on 9 hour acid control studies during the day and 12 hour acid control studies at night. Acid control does not imply symptom relief.
3. Prevents heartburn if taken 15-60 minutes before a meal.
4. Starts to neutralize acid on contact.
5. Prevents heartburn if taken 10-60 minutes before a meal.
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