H2 BLOCKER VS. ANTACID VS. PPI

THERE ARE VARIOUS TREATMENT OPTIONS FOR ACID REFLUX AND HEARTBURN. THE THREE MAIN CATEGORIES OF PRODUCTS INCLUDE HISTAMINE-2 BLOCKERS (H2 BLOCKERS), ANTACIDS, AND PROTON PUMP INHIBITORS (PPIS). LEARN MORE ABOUT EACH OF THEM AND REMEMBER TO SPEAK WITH YOUR HEALTHCARE PROVIDER ABOUT WHICH TREATMENT OPTION MIGHT BE RIGHT FOR YOU.

H2 BLOCKERS

H2 blockers are intended to treat unexpected heartburn and lower the amount of acid your stomach produces by blocking the histamine receptors in your stomach that are responsible for triggering acid production. H2 blockers (like PEPCID®) start relieving heartburn symptoms in just 15-30 minutes and control acid for up to 12 hours.

ANTACIDS

Antacids, like Tums®, are intended to treat unexpected heartburn and neutralize the acid in your stomach, but they don’t block production of more acid. Antacids work quickly, but effects may last up to 2 hours per dose.

PROTON PUMP INHIBITORS (PPIs)

PPIs, like Nexium® and Prilosec®, work by shutting down pumps that release acid into your stomach. PPIs require a 14-day regimen, are intended to treat frequent heartburn, and are not intended for immediate relief. In fact, PPIs may take 1-4 days to fully work*. For consistent heartburn relief you’ll need to keep an even more consistent dosing schedule.

*Some consumers will experience complete relief in 24 hours.

Third party trademarks used herein are trademarks of their respective owners.

COMPARE H2 BLOCKER (PEPCID®) VS. ANTACID VS. PPI

PEPCID® is an FDA approved, safe and effective remedy to relieve symptoms of occasional heartburn when used as directed.

Product

H2 BLOCKER & ANTACID

PEPCID COMPLETE®

H2 BLOCKER

ORIGINAL & MAXIMUM STRENGTH PEPCID AC®

ANTACID

TUMS®

PROTON PUMP INHIBITOR (PPI)

NEXIUM® 24HR/ PRILOSEC OTC®

Active Ingredient

Famotidine

(Acid Reducer)

Calcium Carbonate

(Antacid)

Magnesium Hydroxide

(Antacid)

Famotidine

(Acid Reducer)

Calcium Carbonate

(Antacid)

Esomeprazole/Omeprazole

(Acid Reducer)
Intended use

Treats unexpected heartburn

Treats and prevents unexpected heartburn

Treats unexpected heartburn

Treats frequent heartburn

Adult dosing

1 tablet

1 tablet

2-4 tablets

1 pill every day for 14 days

Onset of heartburn relief

Starts to work in seconds²

Starts to work in minutes¹

Starts to work in seconds²

Not intended for immediate relief. Can take up to 1-4 days for full effect

Duration of acid control or

Up to 12 hours⁴

Up to 12 hours⁴

Up to 2 hours

Up to 24 hours (when taken once daily for 14 days)

One dose provides acid control through the night
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Prevents heartburn before it happens
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Drug interactions (per label)

Ask your doctor or pharmacist before use if you are currently taking a prescription drug. Antacids may interact with certain prescription drugs.

Ask your doctor or pharmacist before use if you are currently taking a prescription drug. Antacids may interact with certain prescription drugs.

Ask your doctor or pharmacist before use if you are currently taking a prescription drug. Antacids may interact with certain prescription drugs.

Ask you doctor or pharmacist before use if you are taking Warfarin, clopidogrel, or cilostazol (blood-thinning medicines)

Prescription anti-fungal or anti-yeast medicines

Diogoxin (heart medicine)

Diazepam (anxiety medicine)

Tacrolimus or mycophenolate mofetil (immune system medicine)

Prescription antiretrovirals (medicines for HIV infection)

Methotrexate (arthritis medicine)